Transcriptomic Down-Regulation of Immune System Components in Barrier and Hematopoietic Tissues after Lipopolysaccharide Injection in Antarctic Notothenia coriiceps

The environmental conditions and isolation in the Antarctic have driven evolution of a unique biodiversity at macro to microorganism scale. Here, we investigated possible adaptation teleost Nototheniacoriiceps immune system cold environment microbial community Southern Ocean. fish was stimulated through an intraperitoneal injection lipopolysaccharide (LPS 0111:B4 from E. coli) tissue transcriptomic response plasma biochemistry were analyzed 7 days later compared sham injected control. Gene transcription head-kidney, intestine skin significantly modified by LPS, although tissues showed different responsiveness, with duodenum most least modified. processes related cell metabolism (up-regulated) (comprising 30% differentially expressed genes). identified mostly down-regulated, particularly interleukins pattern recognition receptors (PRRs), nucleotide-binding oligomerization domain-like mannose receptors, unlike toll-like commonly described other fish. transcriptional not mirrored systemic response, as circulating levels enzymes innate immunity, lysozyme antiproteases, untreated control In conclusion, while N.coriiceps shares many features teleosts there are also some specificities. Further studies should better characterize PRRs their role teleosts, well importance LPS source its consequences for activation teleosts.